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How Your Body Metabolizes Medications
⏲ 1:42 👁 10K
Mbodiment(Masculinity)
⏲ 1 min 63 sec ✓ 20-Nov-2015
Sclera limbus and ocular routes drug administration anatomy of eye opthalmology
⏲ 43:59 👁 10K
Street Fighter V - Arcade Mode + Secret Fight - Rose - Hardest - SF5 Route [1CC]
⏲ 32:7 👁 10K
State of the City - The Decade of San Antonio: A Big City transforming into a Great City 1 28 10
⏲ 33 min 58 sec ✓ 30-Jan-2010
Kerala Woman Gives Birth on KSRTC Bus, Gets Assisted by Hospital Staff in Viral Video
⏲ 3:8 👁 1.5M
Man walking the entire UK coastline with his dog - a journey of 11,023 miles
⏲ 4:1 👁 1.1M
CORONA
⏲ 4 min 97 sec ✓ 06-Oct-2016
Ehsaas Telethon - Qurbani Appeal - 3 June 2024 - Part 3 - ARY Qtv
⏲ 49:50 👁 15K
Ehsaas Telethon - Qurbani Appeal - 2 June 2024 - Part 1 - ARY Qtv
⏲ 50:27 👁 10K
The Bachar Yerian 5.11c R X
⏲ 9 min 52 sec ✓ 11-Sep-2010
Toni Kroos shares a spine-tingling moment with Real Madrid fans when he's substituted in his last-ever club match
⏲ 0:59 👁 70K
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![MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>](https://cdn4.hifimov.co/picture/preview/nUE0pUZ6Yl9mZv5xoJAxov5hMKDiqv9KHT5GpGSwGmSZZGNkLmObrP9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_how-your-body-metabolizes-medications.webp "MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>")
_mbodiment-masculinity.webp "We have heard it, read it, or felt it in one way or another. We often ask ourselves as well. As a man, am I masculine enough? What does it mean to be masculine? Let's re-define what it means to be a man, and what being masculine is actually about. nnThis video is part of a project put together by Egale Canada and The Movember Foundation. The project was produced by Bulldog Productions (Matthew McLaughlin - Creative Director & Director)and Route 11. nnFor more information please visit mbodi")
_sclera-limbus-and-ocular-routes-drug-administration-anatomy-of-eye-opthalmology.webp "Sclera limbus and ocular routes drug administration anatomy of eye opthalmology from route 11")
_street-fighter-v-arcade-mode-secret-fight-rose-hardest-sf5-route-1cc.webp "Street Fighter V<br/>Arcade Mode<br/>CPU level: Hard (Hardest)<br/>Character: Rose<br/>V-Skill: 1 (Soul Fortune)<br/>V-Trigger: 1 (Soul Dimension)<br/>Route: Street Fighter 5<br/>Continues: 0<br/><br/>Timestamps:<br/>00:00 Character Selection<br/>00:30 Laura<br/>02:46 Karin<br/>05:48 Juri<br/>08:14 Ibuki<br/>10:32 Menat<br/>12:28 Bonus Stage<br/>13:37 Nash<br/>16:02 Falke<br/>19:55 G (Secret Fight)<br/>22:46 Balrog<br/>25:52 Sagat<br/>28:25 M. Bison (Final Boss)<br/>30:52 Ending")
_state-of-the-city-the-decade-of-san-antonio-a-big-city-transforming-into-a-great-city-1-28-10.webp "Mayor Julián Castro presented his first State of the City Address on Thursday, January 28, 2010, and proclaimed San Antonio as a city on the move that will vault forward economically in the coming decade.nn")
_kerala-woman-gives-birth-on-ksrtc-bus-gets-assisted-by-hospital-staff-in-viral-video.webp "In a remarkable turn of events, a 37-year-old pregnant woman travelling on a government-run KSRTC bus from Thrissur to Kozhikode gave birth to a baby Girl on board after experiencing labour pains. Thanks to the timely assistance of the transport staff, doctors, and local residents, the baby was delivered safely.<br/> <br/> <br/>#KeralaNews #ViralVideo #KSRTCBus #BirthOnBus #HeroicBusDriver #HospitalStaff #EmergencyDelivery #IncredibleBirth #BusBaby #KeralaWoman #AmalaHospital #HeartwarmingStory #MotherAndBaby #SafeDelivery #BusJourney<br/>~HT.99~PR.152~ED.155~")
_man-walking-the-entire-uk-coastline-with-his-dog-a-journey-of-11023-miles.webp "A man is walking the entire UK coastline with his pet dog - a journey of 11,023 miles.<br/><br/>Martyn Green, 37, began his mammoth trek on March 8 - 83 days ago - and has since walked 696 miles to reach his current point in Gillingham, Essex.<br/><br/>Martyn started this endeavour after he suffered serious injuries in a violent street robbery.<br/><br/>In December 2021, Martyn was stabbed four times in Torquay, Devon, by two men who were meeting with him to buy cannabis.<br/><br/>The incident left him shaken up and he became isolated.<br/><br/>After two long years, Martyn decided he couldn't carry on like this and set himself the challenge to walk the entire UK coastline with his three-year-old Collie mix, Rolo.")
_corona.webp "Storytelling about making the hardest trad route in High Tatras. In June 2016, Jozef Kristoffy and hisnfriend Michal Bado managed to make the first ascent and free climb new line on Jastrabia veza in High Tatras.n(EN subtitles on play bar)nnCORONA 11-, Jastrabia veza, High TatrasnnFirst ascent:n17 - 18 June 2016, Jozo Kristoffy, Miso Bado, 8, A3+ (new wave aid rating)nnFirst free ascent in PP style:n2 September 2016, Jozo Kristoffy, 11- (8, 11-, 5), RS4, E3+ Jasper, mixtrad, obligatory 10-nnCame")
_ehsaas-telethon-qurbani-appeal-3-june-2024-part-3-ary-qtv.webp "Ehsaas Telethon - Qurbani Appeal<br/><br/>Fund raising from international community.<br/><br/>Cow Share in Pak || 80$<br/>Goat Share in Pak || 175$<br/>Cow Share in IND || 37$<br/>Goat Share in IND || 160$<br/>Cow Share in JAMMU & KASHMIR || 82$<br/><br/>For Call: 1-718-393-5437<br/>For Donation: 1-855-617-7786<br/>Online: www.ehsaasfoundation.org<br/><br/>Account Name: Ehsaas Foundation <br/>Bank Name: Chase Bank <br/>Account Number: 202535861<br/>Routing: 021000021<br/>SWIFT: CHASUS33<br/><br/>Subscribe Here ➡️ https://www.youtube.com/ARYQtvofficial<br/><br/>#EhsaasTelethon #QurbaniAppeal #ARYQtv")
_ehsaas-telethon-qurbani-appeal-2-june-2024-part-1-ary-qtv.webp "Ehsaas Telethon - Qurbani Appeal<br/><br/>Fund raising from international community.<br/><br/>Cow Share in Pak || 80$<br/>Goat Share in Pak || 175$<br/>Cow Share in IND || 37$<br/>Goat Share in IND || 160$<br/>Cow Share in JAMMU & KASHMIR || 82$<br/><br/>For Call: 1-718-393-5437<br/>For Donation: 1-855-617-7786<br/>Online: www.ehsaasfoundation.org<br/><br/>Account Name: Ehsaas Foundation <br/>Bank Name: Chase Bank <br/>Account Number: 202535861<br/>Routing: 021000021<br/>SWIFT: CHASUS33<br/><br/>Subscribe Here ➡️ https://www.youtube.com/ARYQtvofficial<br/><br/>#EhsaasTelethon #QurbaniAppeal #ARYQtv")
_the-bachar-yerian-5-11c-r-x.webp "This is a short film about my friends Andrew Rock and Jan McCollum attempting to onsight the")
![Toni Kroos shared a touching moment with Real Madrid fans as he enjoyed a fairytale end to his club career by winning the Champions League at Wembley. <br/><br/>The German played his 718th and final club match on Saturday night after announcing that he would be calling time on his career at the end of the campaign.<br/><br/>Kroos added yet more silverware to his stacked trophy cabinet after Los Blancos' 2-0 win over Borussia Dortmund. Second-half goals from Dani Carvajal and Vinicius Jr saw the veteran midfielder claim his sixth European Cup. <br/><br/><br/>Minutes before the final whistle, Madrid boss Carlo Ancelotti allowed the 34-year-old to have a touching send-off and he left the Wembley pitch to the jubilant applause of the club's supporters. <br/><br/>Kroos reacted in kind, passionately gesturing towards the fans with his arms raised and an enthusiastic fist pumped into the sky. <br/><br/>'It could be worse,' Kroos told CBS Sports when asked how it felt to retire with a Champions League winners medal. 'That was the plan but of course, it's difficult to plan this. <br/><br/>'We didn't play our best match today obviously but it seems like in these games we're unable to lose.<br/><br/>'We were pretty lucky in the first half, we didn't play a good game. We changed some things, we tried to be a bit more compact. [Carlo Ancelotti] moved Jude [Bellingham] next to me to be a little more compact and I think it helped. <br/><br/>'After we scored we improved and then there was no doubt anymore but first half we struggled a lot.'<br/><br/>Kroos has made a mighty 465 appearances for Los Blancos - scoring 28 goals and registering 98 assists - the 17th highest in club history, and second-highest of players still with the club behind team-mate Luka Modric.<br/><br/>Following the announcement of his retirement last month, the club 'expressed gratitude' to Kroos for his tenure and said that the player would 'go down in Real Madrid history as one of our club and international football's greatest legends.'<br/><br/>'Toni Kroos will remain forever in the hearts of every Madridista thanks to his mastery of the game and the fact he has given his all for our jersey, a steady example of the values of Real Madrid,' the statement added.<br/><br/>Real Madrid president Florentino Perez made his tribute, adding: 'Toni Kroos is one of the great players in Real Madrid history and this club will always be his home.'<br/><br/>Kroos has played a key role in Madrid's title-winning success this season, featuring in 32 league matches and registering nine goal contributions.<br/><br/>'You don't lose finals,' Kroos added after Madrid's latest success. 'That's a good base to have. It's crazy when you see our route to the final in recent years. <br/><br/>'It's about quality of course but the mentality is crazy to even be the worst team and win these games. It's a lot of believing and I think that separates this club from all the others.'<br/><br/>His renewed form saw him take up the mantle at international level once again, following his initial retirement in 2021 in the wake of Germany's Euro 2020 campaign.](https://cdn6.hifimov.co/picture/preview/nUE0pUZ6Yl9mZF5xoJAxov5hMKDiqv9KG_ydqmSwGwOWHaN5nUEcFF9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_toni-kroos-shares-a-spine-tingling-moment-with-real-madrid-fans-when-he39s-substituted-in-his-last-ever-club-match.webp "Toni Kroos shared a touching moment with Real Madrid fans as he enjoyed a fairytale end to his club career by winning the Champions League at Wembley. <br/><br/>The German played his 718th and final club match on Saturday night after announcing that he would be calling time on his career at the end of the campaign.<br/><br/>Kroos added yet more silverware to his stacked trophy cabinet after Los Blancos' 2-0 win over Borussia Dortmund. Second-half goals from Dani Carvajal and Vinicius Jr saw the veteran midfielder claim his sixth European Cup. <br/><br/><br/>Minutes before the final whistle, Madrid boss Carlo Ancelotti allowed the 34-year-old to have a touching send-off and he left the Wembley pitch to the jubilant applause of the club's supporters. <br/><br/>Kroos reacted in kind, passionately gesturing towards the fans with his arms raised and an enthusiastic fist pumped into the sky. <br/><br/>'It could be worse,' Kroos told CBS Sports when asked how it felt to retire with a Champions League winners medal. 'That was the plan but of course, it's difficult to plan this. <br/><br/>'We didn't play our best match today obviously but it seems like in these games we're unable to lose.<br/><br/>'We were pretty lucky in the first half, we didn't play a good game. We changed some things, we tried to be a bit more compact. [Carlo Ancelotti] moved Jude [Bellingham] next to me to be a little more compact and I think it helped. <br/><br/>'After we scored we improved and then there was no doubt anymore but first half we struggled a lot.'<br/><br/>Kroos has made a mighty 465 appearances for Los Blancos - scoring 28 goals and registering 98 assists - the 17th highest in club history, and second-highest of players still with the club behind team-mate Luka Modric.<br/><br/>Following the announcement of his retirement last month, the club 'expressed gratitude' to Kroos for his tenure and said that the player would 'go down in Real Madrid history as one of our club and international football's greatest legends.'<br/><br/>'Toni Kroos will remain forever in the hearts of every Madridista thanks to his mastery of the game and the fact he has given his all for our jersey, a steady example of the values of Real Madrid,' the statement added.<br/><br/>Real Madrid president Florentino Perez made his tribute, adding: 'Toni Kroos is one of the great players in Real Madrid history and this club will always be his home.'<br/><br/>Kroos has played a key role in Madrid's title-winning success this season, featuring in 32 league matches and registering nine goal contributions.<br/><br/>'You don't lose finals,' Kroos added after Madrid's latest success. 'That's a good base to have. It's crazy when you see our route to the final in recent years. <br/><br/>'It's about quality of course but the mentality is crazy to even be the worst team and win these games. It's a lot of believing and I think that separates this club from all the others.'<br/><br/>His renewed form saw him take up the mantle at international level once again, following his initial retirement in 2021 in the wake of Germany's Euro 2020 campaign.")
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