_estrogen-receptor-mutations-detected-in-plasma-associated-with-worse-overall-survival-in-metastatic-breast-cancer.jpg "Estrogen receptor mutations detected in plasma associated with worse overall survival in metastatic breast cancer from dna in blood sample Video Screenshot Preview")
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⏲ Duration: 4 min 84 sec
✓ Published: 11-Oct-2017
✓ Published: 11-Oct-2017
Description:
Dr Chandarlapaty talks to ecancertv at SABCS 2015 about the results of a study looking at two genetic mutations in the estrogen receptor 1 gene (ESR1) and how this affected the outcomes of women with estrogen receptor-positive metastatic breast cancer.nnThe Y537S and D538G mutations in ESR1 are common alterations seen in metastatic breast cancer and result in making the receptor estrogen independent and can results in resistance to estrogen deprivation therapy such as an aromatase inhibitor.nnUs
Dr Chandarlapaty talks to ecancertv at SABCS 2015 about the results of a study looking at two genetic mutations in the estrogen receptor 1 gene (ESR1) and how this affected the outcomes of women with estrogen receptor-positive metastatic breast cancer.nnThe Y537S and D538G mutations in ESR1 are common alterations seen in metastatic breast cancer and result in making the receptor estrogen independent and can results in resistance to estrogen deprivation therapy such as an aromatase inhibitor.nnUs
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