Intercellular transfer of oncolytic virus expressed GFP between cancer cells via a tunneling nanotube (TNT). from bystander effect cancer Watch Video

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✓ Published: 08-Dec-2016
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Time-lapse imaging capturing transfer of eGFP from a NV1066 virus-infected JMN mesothelioma cell to a non-infected cell after de novo TNT formation. From Ady et al., Tunneling nanotubes: an alternate route for propagation of the bystander effect following oncolytic viral infection, published in Molecular Therapy Oncolytics December 7, 2016. nnDirect link to article: http://www.nature.com/articles/mto201629

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Additional time-lapse evidence of TNT formation between JMN (mesothelioma/cancer) cells infected or not infected with eGFP-expressing NV1066 virus (engineered form of oncolytic herpes simplex virus). Note the conformation of the TNT and its length >75 µm.nMovie S2 from Supplementary Information section of Ady et al., Tunneling nanotubes: an alternate route for propagation of the bystander effect following oncolytic viral infection, published in Molecular Therapy Oncolytics December 7, 2016. nnD
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